EXOSC6 and NDUFA13

Data Source:
HPRD (two hybrid)

		EXOSC6	NDUFA13
Description		exosome component 6	NADH:ubiquinone oxidoreductase subunit A13
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respirasome Mitochondrial Respiratory Chain Complex I Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	RNA Binding Exoribonuclease Activity	NADH Dehydrogenase Activity Protein Binding ATP Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Peptidase Activity Viral Process Negative Regulation Of Cell Growth Mitochondrial Respiratory Chain Complex I Assembly Cellular Response To Interferon-beta Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Retinoic Acid Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872)
Interacting Genes		37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36	7 interacting genes: EXOSC6 HSPB2 KRAS LIG4 STAT3 UBE3A XRN1
Entrez ID		118460	51079
HPRD ID		12107	09452
Ensembl ID		ENSG00000223496	ENSG00000186010
Uniprot IDs		Q5RKV6	Q9P0J0
PDB IDs		2NN6 6D6Q 6D6R 6H25	5XTB 5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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