EXOSC6 and MOCS3

Data Source:
HPRD (two hybrid)

		EXOSC6	MOCS3
Description		exosome component 6	molybdenum cofactor synthesis 3
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol	Cytoplasm Cytosol
	Molecular Function	RNA Binding Exoribonuclease Activity	Thiosulfate Sulfurtransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity Sulfurtransferase Activity URM1 Activating Enzyme Activity Metal Ion Binding Molybdopterin-synthase Sulfurtransferase Activity Molybdopterin-synthase Adenylyltransferase Activity
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	TRNA Wobble Uridine Modification TRNA Wobble Position Uridine Thiolation Mo-molybdopterin Cofactor Biosynthetic Process Protein Phosphopantetheinylation Molybdopterin Cofactor Biosynthetic Process Protein Urmylation TRNA Thio-modification
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Molybdenum cofactor biosynthesis
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36	3 interacting genes: EXOSC6 MOCS2 XRN2
Entrez ID		118460	27304
HPRD ID		12107	10092
Ensembl ID		ENSG00000223496	ENSG00000124217
Uniprot IDs		Q5RKV6	O95396
PDB IDs		2NN6 6D6Q 6D6R 6H25	3I2V
Enriched GO Terms of Interacting Partners?
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