EXOSC6 and TUFM

Data Source:
BioGRID (two hybrid)

		EXOSC6	TUFM
Description		exosome component 6	Tu translation elongation factor, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol	Mitochondrion Membrane Mitochondrial Nucleoid Synapse Extracellular Exosome
	Molecular Function	RNA Binding Exoribonuclease Activity	RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Translational Elongation Viral Process Response To Ethanol Mitochondrial Translational Elongation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Mitochondrial translation elongation
Drugs			Zinc Guanosine-5'-Diphosphate Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)	Alcohol consumption (drinks per week) ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 20935630) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663)
Interacting Genes		37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36	18 interacting genes: ARL6IP1 ASPH ATP6V1A CMTM5 DGAT2L6 EXOSC6 FAM9B FUNDC1 HMBOX1 LINC01554 MTIF3 MYH9 PCAT1 PTEN RHBDD2 SYP TNFRSF10D ZDHHC15
Entrez ID		118460	7284
HPRD ID		12107	03861
Ensembl ID		ENSG00000223496	ENSG00000178952
Uniprot IDs		Q5RKV6	A0A384ME17 P49411
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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