EXOSC6 and RAB3GAP2

Data Source:
HPRD (two hybrid)

		EXOSC6	RAB3GAP2
Description		exosome component 6	RAB3 GTPase activating non-catalytic protein subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	RNA Binding Exoribonuclease Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Enzyme Activator Activity Enzyme Regulator Activity Small GTPase Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Intracellular Protein Transport Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Martsolf syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast size ( 27182965)
Interacting Genes		37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36	3 interacting genes: EXOSC6 FEZ1 RAB3GAP1
Entrez ID		118460	25782
HPRD ID		12107	11471
Ensembl ID		ENSG00000223496	ENSG00000118873
Uniprot IDs		Q5RKV6	Q9H2M9
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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