GLIS2 and FZR1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GLIS2	FZR1
Description		GLIS family zinc finger 2	fizzy and cell division cycle 20 related 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Non-motile Cilium	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Anaphase-promoting Complex Binding Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development Cell Differentiation Involved In Kidney Development Hematopoietic Stem Cell Homeostasis Positive Regulation Of Protein Localization To Nucleus	DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Cell Population Proliferation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Division Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint Negative Regulation Of Cell Aging Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways			Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693)	Red cell distribution width ( 32888494)
Interacting Genes		92 interacting genes: ACTN3 AKAP9 AKT1 ANKRD36B ARAF ARID5A ARNT BCAR1 BECN1 C19orf54 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CREM CRX CSNK2B CTBP2 CTNNB1 EPHA2 ERBB2 FAM168B FGFR4 FOSB FZR1 GLIS1 GMNN GOLGA6L9 GPSM1 GPSM2 HGF HIF1A KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NME7 NSD3 OIP5 PIK3CA PLEKHB1 PLEKHB2 POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RAF1 RASSF1 RBFOX2 RBM11 RBPMS SHOX SOX3 SPECC1L STK11 TEAD2 TENT5A TERT TLE5 TRIM32 TSC1 TWIST2 U2AF2 VAC14 VBP1 VENTX WNK1 WT1 WWOX XAB2 ZRANB1	96 interacting genes: AKT1 AKT1S1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC5 ANAPC7 ARNT AURKA BECN1 BEX1 BLID BTRC BUB1B C7orf25 CCL5 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC20 CDC25A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2A CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PCLAF PDGFRA PLK1 PSMC3IP PTP4A3 PTTG1 RASSF1 RBBP8 SASS6 SENP2 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TEAD2 TERT THRSP TP53 UBE2C UBE2D1 UBE2D3 UBE2K UBE2S
Entrez ID		84662	51343
HPRD ID		12256	04687
Ensembl ID		ENSG00000126603	ENSG00000105325
Uniprot IDs		B3KTH4 Q9BZE0	Q9UM11
PDB IDs			4UI9 5L9T 5L9U
Enriched GO Terms of Interacting Partners?
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