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GLIS2 and CCNE1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
GLIS2
CCNE1
Description
GLIS family zinc finger 2
cyclin E1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Non-motile Cilium
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cyclin E1-CDK2 Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Central Nervous System Development
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development
Cell Differentiation Involved In Kidney Development
Hematopoietic Stem Cell Homeostasis
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
DNA Replication Initiation
Protein Phosphorylation
Homologous Chromosome Pairing At Meiosis
Wnt Signaling Pathway
Mitotic Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Regulation Of Cellular Protein Localization
Pathways
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Association of TriC/CCT with target proteins during biosynthesis
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
PTK6 Regulates Cell Cycle
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
RHOBTB3 ATPase cycle
Drugs
Diseases
Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
Laryngeal cancer
Gastric cancer
GWAS
Erectile dysfunction (
30583798
)
Heel bone mineral density (
30598549
)
Lung function (FEV1/FVC) (
26635082
)
Prostate-specific antigen levels (
28139693
)
Adult body size (
32376654
)
Bladder cancer (
24163127
20972438
)
Body mass index (
25673413
)
Breast cancer (
29058716
)
Breast cancer (estrogen-receptor negative) (
29058716
)
Diastolic blood pressure (
28135244
27841878
)
Medication use (diuretics) (
31015401
)
Response to fenofibrate (total cholesterol levels) (
27002377
)
Spatial processing (
31596458
)
Interacting Genes
92 interacting genes:
ACTN3
AKAP9
AKT1
ANKRD36B
ARAF
ARID5A
ARNT
BCAR1
BECN1
C19orf54
CBLC
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CPSF1
CREM
CRX
CSNK2B
CTBP2
CTNNB1
EPHA2
ERBB2
FAM168B
FGFR4
FOSB
FZR1
GLIS1
GMNN
GOLGA6L9
GPSM1
GPSM2
HGF
HIF1A
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-1
KRTAP6-2
KRTAP8-1
LATS2
MAP2K3
MAP2K5
MAP2K6
MAP3K5
MDM2
MDM4
MET
MYC
NF2
NFIC
NME7
NSD3
OIP5
PIK3CA
PLEKHB1
PLEKHB2
POU6F2
PRKAR1B
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RAF1
RASSF1
RBFOX2
RBM11
RBPMS
SHOX
SOX3
SPECC1L
STK11
TEAD2
TENT5A
TERT
TLE5
TRIM32
TSC1
TWIST2
U2AF2
VAC14
VBP1
VENTX
WNK1
WT1
WWOX
XAB2
ZRANB1
70 interacting genes:
AKT1
AR
ARHGEF5
ARID4A
ARIH1
ARNT
AURKA
BRCA2
BTRC
CABLES1
CALM1
CCND2
CCT4
CDC25A
CDC6
CDK1
CDK2
CDK3
CDK4
CDK6
CDKN1A
CDKN1B
CDKN2A
CDKN2B
CDKN2C
COIL
CUL3
FBXW7
FGFR4
FOXM1
FZR1
GLIS2
GMNC
GRM1
GSK3B
H1-0
H1-1
H1-5
HERC5
KAT2A
LATS2
MARCKS
MCM3
MRE11
MYBL2
MYC
NBN
NF2
PIN1
POLD1
PRC1
PRKAR1A
PTPA
RASSF1
RB1
RBL1
RBL2
REL
RHOBTB3
RRN3
SKP2
SMARCA4
SMARCC1
SMARCD3
SPOP
STK11
TERT
TP73
TSC1
UBTF
Entrez ID
84662
898
HPRD ID
12256
00455
Ensembl ID
ENSG00000126603
ENSG00000105173
Uniprot IDs
B3KTH4
Q9BZE0
A0A0G3DHS8
P24864
V5W5X2
PDB IDs
1W98
5L2W
Enriched GO Terms of Interacting Partners
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