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FZR1 and CCNF
Data Source:
BioGRID
(enzymatic study)
FZR1
CCNF
Description
fizzy and cell division cycle 20 related 1
cyclin F
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nuclear Membrane
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Cytoplasm
Centrosome
Centriole
Cytosol
SCF Ubiquitin Ligase Complex
Cell Junction
Molecular Function
Protein Binding
Anaphase-promoting Complex Binding
Ubiquitin Ligase Activator Activity
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Biological Process
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Positive Regulation Of Cell Population Proliferation
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Meiotic Nuclear Division
Positive Regulation Of Protein Catabolic Process
Cell Division
Lens Fiber Cell Differentiation
Protein K11-linked Ubiquitination
Signal Transduction Involved In G2 DNA Damage Checkpoint
Negative Regulation Of Cell Aging
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Polyubiquitination
Re-entry Into Mitotic Cell Cycle
Placenta Development
Negative Regulation Of Centrosome Duplication
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Mitotic Cell Cycle Phase Transition
Cell Division
Pathways
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Red cell distribution width (
32888494
)
Height (
28552196
)
Triglyceride levels (
32203549
)
Interacting Genes
96 interacting genes:
AKT1
AKT1S1
ANAPC1
ANAPC10
ANAPC11
ANAPC2
ANAPC5
ANAPC7
ARNT
AURKA
BECN1
BEX1
BLID
BTRC
BUB1B
C7orf25
CCL5
CCNB1
CCND2
CCNE1
CCNF
CDC14A
CDC20
CDC25A
CDC27
CDC6
CDK2
CDK4
CDK5
CDK6
CDKN2A
CDKN2B
CDR2
CDT1
CLSPN
CYP17A1
DCPS
DKK3
DNAJA1
DNM1L
E2F3
EPHA2
EPSTI1
ERBB2
FBXO5
FGFR4
GLIS2
GMNN
HECW2
HIF1A
KAT2A
KIF18B
LATS2
MAD2L2
MAK
MAP2K3
MAP2K5
MAP3K5
MAPK8
MET
MOAP1
MTA3
MYC
NAT2
NEDD9
NEK2
NF2
OTUD7B
PAX3
PCLAF
PDGFRA
PLK1
PSMC3IP
PTP4A3
PTTG1
RASSF1
RBBP8
SASS6
SENP2
SIRT2
SKIL
SKP2
SMURF1
SOX2
SOX4
SRC
STK11
TEAD2
TERT
THRSP
TP53
UBE2C
UBE2D1
UBE2D3
UBE2K
UBE2S
7 interacting genes:
AKT1
CCNB1
CDC6
FZR1
MYBL2
RBPJ
SCYL1
Entrez ID
51343
899
HPRD ID
04687
02574
Ensembl ID
ENSG00000105325
ENSG00000162063
Uniprot IDs
Q9UM11
P41002
Q59HD0
PDB IDs
4UI9
5L9T
5L9U
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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