TPST1 and CCR8

Data Source:
HPRD (in vitro)

		TPST1	CCR8
Description		tyrosylprotein sulfotransferase 1	C-C motif chemokine receptor 8
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Golgi Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity	Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Peptidyl-tyrosine Sulfation Inflammatory Response Protein Phosphopantetheinylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process	Chemotaxis Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Cytosolic sulfonation of small molecules Gamma carboxylation, hypusine formation and arylsulfatase activation Defective F8 sulfation at Y1699	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Gout ( 22179738)	Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		6 interacting genes: CCR1 CCR8 CMKLR1 GP1BA GPR1 SELPLG	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		8460	1237
HPRD ID		07216	03497
Ensembl ID		ENSG00000169902	ENSG00000179934
Uniprot IDs		A0A024RDK9 O60507	P51685
PDB IDs		5WRI 5WRJ
Enriched GO Terms of Interacting Partners?
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