TPST1 and GP1BA

Data Source:
HPRD (in vivo)

		TPST1	GP1BA
Description		tyrosylprotein sulfotransferase 1	glycoprotein Ib platelet subunit alpha
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Golgi Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Anchored Component Of External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity	Protein Binding Thrombin-activated Receptor Activity
	Biological Process	Peptidyl-tyrosine Sulfation Inflammatory Response Protein Phosphopantetheinylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Regulation Of Megakaryocyte Differentiation Thrombin-activated Receptor Signaling Pathway Platelet Aggregation
Pathways		Cytosolic sulfonation of small molecules Gamma carboxylation, hypusine formation and arylsulfatase activation Defective F8 sulfation at Y1699	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation
Drugs			Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases			Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Blood protein levels ( 30072576 29875488) Gout ( 22179738)	Blood protein levels ( 30072576 29875488) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: CCR1 CCR8 CMKLR1 GP1BA GPR1 SELPLG	17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		8460	2811
HPRD ID		07216	01976
Ensembl ID		ENSG00000169902	ENSG00000185245
Uniprot IDs		A0A024RDK9 O60507	L7UYB8 P07359
PDB IDs		5WRI 5WRJ	1GWB 1K13 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6
Enriched GO Terms of Interacting Partners?
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