JAGN1 and TNFSF14

Data Source:
BioGRID (two hybrid)

		JAGN1	TNFSF14
Description		jagunal homolog 1	TNF superfamily member 14
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Neutrophil Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Tunicamycin Neutrophil Migration	Apoptotic Process Immune Response Signal Transduction T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling
Pathways			TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)
Interacting Genes		126 interacting genes: AGPAT4 APP AQP6 ARL13B BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 C4orf3 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM199 TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VSIG4 VTI1B	22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		84522	8740
HPRD ID		13749	05157
Ensembl ID		ENSG00000171135	ENSG00000125735
Uniprot IDs		Q8N5M9	O43557
PDB IDs			4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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