JAGN1 and CYP4F2

Data Source:
BioGRID (two hybrid)

		JAGN1	CYP4F2
Description		jagunal homolog 1	cytochrome P450 family 4 subfamily F member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytoplasm Endoplasmic Reticulum Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Arachidonic Acid Epoxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Arachidonic Acid Omega-hydroxylase Activity Alpha-tocopherol Omega-hydroxylase Activity Tocotrienol Omega-hydroxylase Activity Aromatase Activity
	Biological Process	Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Neutrophil Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Tunicamycin Neutrophil Migration	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Icosanoid Metabolic Process Leukotriene Metabolic Process Blood Coagulation Regulation Of Blood Pressure Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Icosanoid Secretion Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway
Pathways			Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs
Diseases
GWAS			Acenocoumarol maintenance dosage ( 19578179) Circulating phylloquinone levels ( 25411281) Metabolite levels ( 23281178) Response to Vitamin E supplementation ( 22437554) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Vitamin E levels ( 21729881) Warfarin maintenance dose ( 20833655 19300499)
Interacting Genes		126 interacting genes: AGPAT4 APP AQP6 ARL13B BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 C4orf3 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM199 TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VSIG4 VTI1B	36 interacting genes: - AQP6 CPLX4 CREB3 CREB3L1 DNAJC1 EBP ELOVL4 ERGIC3 FAM210B FCER1G GJA8 HSD17B13 JAGN1 LEPROTL1 MMD MTIF3 MUC1 PGRMC2 PLEKHO1 REEP2 REEP4 RETREG3 SCN3B SDHAF2 SLC10A6 SLC17A8 SLC19A3 SLC2A13 THAP4 TLCD4 TM4SF19 TMEM51 TMEM82 TMX2 UBE2I
Entrez ID		84522	8529
HPRD ID		13749	05112
Ensembl ID		ENSG00000171135	ENSG00000186115
Uniprot IDs		Q8N5M9	P78329
PDB IDs
Enriched GO Terms of Interacting Partners?
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