TNFSF14 and LHFPL3

Data Source:
BioGRID (two hybrid)

		TNFSF14	LHFPL3
Description		TNF superfamily member 14	LHFPL tetraspan subfamily member 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling	Sensory Perception Of Sound
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Autism spectrum disorder or schizophrenia ( 28540026) Diverticular disease ( 30177863) Educational attainment ( 23722424) Gout ( 22179738) Initial pursuit acceleration ( 29064472) Obesity ( 21552555) Regular attendance at a religious group ( 29970889) Response to lithium treatment in bipolar disorder ( 26806518) Social communication problems ( 24564958) Weight ( 28552196)
Interacting Genes		22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2	3 interacting genes: PIGP RNF24 TNFSF14
Entrez ID		8740	375612
HPRD ID		05157	17273
Ensembl ID		ENSG00000125735	ENSG00000187416
Uniprot IDs		O43557	A1L384 Q86UP9
PDB IDs		4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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