TNFSF14 and TMEM11

Data Source:
BioGRID (two hybrid)

		TNFSF14	TMEM11
Description		TNF superfamily member 14	transmembrane protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane	Mitochondrion Integral Component Of Plasma Membrane Integral Component Of Mitochondrial Inner Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Molecular_function Protein Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling	Mitochondrion Organization Inner Mitochondrial Membrane Organization
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Cristae formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)	Body mass index ( 26426971) Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2	53 interacting genes: ARL13B BDKRB2 BIK BNIP3 BNIP3L CCDC70 CCR4 CD79A CLDN7 CLN8 CREB3L1 CYB561 CYB5D2 DRD2 EBP ELOVL4 FAM174A FAM209A FAM210B FATE1 FFAR2 GJB4 GORAB KASH5 LEPROTL1 LMNA MRM1 MSMO1 MTIF3 MUC1 NDUFS3 OTX2 PDZK1IP1 PEX12 RETREG3 RIC3 RNASEH1 SCMH1 SGCB SLC10A6 SLC30A8 SUSD3 SUV39H1 TEX29 TMEM106C TMEM14B TMEM205 TMEM237 TMEM88 TMIE TMPRSS2 TNFSF14 YIPF6
Entrez ID		8740	8834
HPRD ID		05157	12680
Ensembl ID		ENSG00000125735	ENSG00000178307
Uniprot IDs		O43557	P17152
PDB IDs		4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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