SLX4 and GLIS2

Data Source:
BioGRID (affinity chromatography technology)

		SLX4	GLIS2
Description		SLX4 structure-specific endonuclease subunit	GLIS family zinc finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Non-motile Cilium
	Molecular Function	DNA Binding Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Enzyme Binding Metal Ion Binding 3'-flap Endonuclease Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development Cell Differentiation Involved In Kidney Development Hematopoietic Stem Cell Homeostasis Positive Regulation Of Protein Localization To Nucleus
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Type 2 diabetes ( 32499647)	Erectile dysfunction ( 30583798) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693)
Interacting Genes		8 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A UBC UBE2I	92 interacting genes: ACTN3 AKAP9 AKT1 ANKRD36B ARAF ARID5A ARNT BCAR1 BECN1 C19orf54 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CREM CRX CSNK2B CTBP2 CTNNB1 EPHA2 ERBB2 FAM168B FGFR4 FOSB FZR1 GLIS1 GMNN GOLGA6L9 GPSM1 GPSM2 HGF HIF1A KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NME7 NSD3 OIP5 PIK3CA PLEKHB1 PLEKHB2 POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RAF1 RASSF1 RBFOX2 RBM11 RBPMS SHOX SOX3 SPECC1L STK11 TEAD2 TENT5A TERT TLE5 TRIM32 TSC1 TWIST2 U2AF2 VAC14 VBP1 VENTX WNK1 WT1 WWOX XAB2 ZRANB1
Entrez ID		84464	84662
HPRD ID		12537	12256
Ensembl ID		ENSG00000188827	ENSG00000126603
Uniprot IDs		Q8IY92	B3KTH4 Q9BZE0
PDB IDs		4M7C 4UYI 4ZOU
Enriched GO Terms of Interacting Partners?
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