SLX4 and EME1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SLX4	EME1
Description		SLX4 structure-specific endonuclease subunit	essential meiotic structure-specific endonuclease 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex	Heterochromatin Nucleoplasm Nucleolus Holliday Junction Resolvase Complex
	Molecular Function	DNA Binding Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Enzyme Binding Metal Ion Binding 3'-flap Endonuclease Activity	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Type 2 diabetes ( 32499647)
Interacting Genes		8 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A UBC UBE2I	6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2
Entrez ID		84464	146956
HPRD ID		12537	10937
Ensembl ID		ENSG00000188827	ENSG00000154920
Uniprot IDs		Q8IY92	Q96AY2
PDB IDs		4M7C 4UYI 4ZOU	2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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