TMIE and VAPA

Data Source:
BioGRID (two hybrid)

		TMIE	VAPA
Description		transmembrane inner ear	VAMP associated protein A
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function		Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Cadherin Binding Protein Heterodimerization Activity
	Biological Process	Sensory Perception Of Sound Inner Ear Morphogenesis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Cell Death Viral Process Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways			Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Deafness, autosomal recessive
GWAS			Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		28 interacting genes: ANKRD28 AQP6 CLRN1 CREB3L1 EBP FAM210B HMOX1 JAGN1 KRT34 KRTAP10-8 KRTAP12-3 MDFI NBPF19 NOTCH2NLA PLPP6 PLPPR2 RHBDD1 SEC22A SLC14A1 SUMO1 TLCD4 TMEM101 TMEM11 TMEM14B TMEM242 TMEM51 TMPPE VAPA	39 interacting genes: ADGRG7 ADRB2 APOD APP AQP6 CACNG1 CD79A CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B11 HSD17B13 JAGN1 KCNB1 LEPROTL1 NSF OPRM1 OSBP PGRMC2 RETREG3 RMDN2 SCN3B SEC11C SIK1 SLC16A7 SLC35B1 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 VAMP1 VAMP2 ZBTB22
Entrez ID		259236	9218
HPRD ID		06252	09299
Ensembl ID		ENSG00000181585	ENSG00000101558
Uniprot IDs		Q8NEW7	Q9P0L0
PDB IDs			2RR3
Enriched GO Terms of Interacting Partners?
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