TMIE and RHBDD1

Data Source:
BioGRID (two hybrid)

		TMIE	RHBDD1
Description		transmembrane inner ear	rhomboid domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function		Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Sensory Perception Of Sound Inner Ear Morphogenesis	Apoptotic Process Positive Regulation Of Protein Processing Membrane Protein Intracellular Domain Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Spermatid Differentiation Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation
Pathways
Drugs
Diseases		Deafness, autosomal recessive
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulmonary function ( 17903307)
Interacting Genes		28 interacting genes: ANKRD28 AQP6 CLRN1 CREB3L1 EBP FAM210B HMOX1 JAGN1 KRT34 KRTAP10-8 KRTAP12-3 MDFI NBPF19 NOTCH2NLA PLPP6 PLPPR2 RHBDD1 SEC22A SLC14A1 SUMO1 TLCD4 TMEM101 TMEM11 TMEM14B TMEM242 TMEM51 TMPPE VAPA	18 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC LPCAT2 LRRK2 MFHAS1 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TMEM42 TMEM86B TMIE
Entrez ID		259236	84236
HPRD ID		06252	13206
Ensembl ID		ENSG00000181585	ENSG00000144468
Uniprot IDs		Q8NEW7	Q8TEB9
PDB IDs			5EPP
Enriched GO Terms of Interacting Partners?
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