POLR1B and EIF3L

Data Source:
HPRD (in vitro)

		POLR1B	EIF3L
Description		RNA polymerase I subunit B	eukaryotic translation initiation factor 3 subunit L
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Cytosol	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ribonucleoside Binding Metal Ion Binding	RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Embryo Implantation RRNA Transcription Nucleologenesis Positive Regulation Of Gene Expression, Epigenetic	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207	12 interacting genes: DNM2 EIF3D EIF3E EIF3K ERCC6 HRAS POLR1B PPP1R18 RGS2 RRN3 SMAD2 XRN2
Entrez ID		84172	51386
HPRD ID		06852	10932
Ensembl ID		ENSG00000125630	ENSG00000100129
Uniprot IDs		B7Z1W6 Q9H9Y6	Q9Y262
PDB IDs			3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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