EIF3L and PPP1R18

Data Source:
BioGRID (two hybrid)

		EIF3L	PPP1R18
Description		eukaryotic translation initiation factor 3 subunit L	protein phosphatase 1 regulatory subunit 18
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Cytoplasm Cytoskeleton
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	Actin Binding Protein Binding Phosphatase Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hemoglobin levels ( 32327693) Lung cancer ( 28604730)
Interacting Genes		12 interacting genes: DNM2 EIF3D EIF3E EIF3K ERCC6 HRAS POLR1B PPP1R18 RGS2 RRN3 SMAD2 XRN2	80 interacting genes: ABRA ACTN3 BICD2 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC88B CDR2L CEP70 COG6 DES DZIP1 EIF3L FAM9B FHL5 FSD2 GCC1 GFAP GMCL1 GOLGA2 GOLGA6L9 GOPC GRIPAP1 GTPBP3 HAP1 HOMER3 HOOK2 HSF2BP IKZF3 KASH5 KCTD9 KRT13 KRT15 KRT16 KRT19 KRT27 KRT31 KRT33B KRT34 KRT36 KRT40 LDOC1 LZTS1 LZTS2 MAD1L1 MAPK1 MEOX2 MID2 MRPL38 MTUS2 NACA NEFL PDE4DIP PIBF1 PLEKHF2 PPP1CA PPP1CC PPP1R13B PRPH SORBS3 SPDL1 STX11 TCF4 TEX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TRIM62 TRIM69 TSC1 TSGA10 VIM VPS52 ZMYND12 ZRANB1
Entrez ID		51386	170954
HPRD ID		10932	11172
Ensembl ID		ENSG00000100129	ENSG00000146112
Uniprot IDs		Q9Y262	A0A024RCJ8 Q6NYC8
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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