EIF3L and RGS2

Data Source:
BioGRID (two hybrid)

		EIF3L	RGS2
Description		eukaryotic translation initiation factor 3 subunit L	regulator of G protein signaling 2
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation	Response To Amphetamine Cell Cycle G Protein-coupled Receptor Signaling Pathway Spermatogenesis Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Ovulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	G alpha (q) signalling events
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		12 interacting genes: DNM2 EIF3D EIF3E EIF3K ERCC6 HRAS POLR1B PPP1R18 RGS2 RRN3 SMAD2 XRN2	61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		51386	5997
HPRD ID		10932	02917
Ensembl ID		ENSG00000100129	ENSG00000116741
Uniprot IDs		Q9Y262	A0A024R939 P41220
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?
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