POLR1B and RRN3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		POLR1B	RRN3
Description		RNA polymerase I subunit B	RRN3 homolog, RNA polymerase I transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Cytosol	Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ribonucleoside Binding Metal Ion Binding	RNA Polymerase I Core Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity
	Biological Process	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Embryo Implantation RRNA Transcription Nucleologenesis Positive Regulation Of Gene Expression, Epigenetic	RNA Polymerase I Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Neuron Projection Development
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape
Drugs
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fruit consumption ( 32066663) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Triglyceride levels ( 32154731)
Interacting Genes		14 interacting genes: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207	10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C
Entrez ID		84172	54700
HPRD ID		06852	12004
Ensembl ID		ENSG00000125630	ENSG00000085721
Uniprot IDs		B7Z1W6 Q9H9Y6	B7ZB55 F5H148 Q9NYV6
PDB IDs
Enriched GO Terms of Interacting Partners?
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