VPS37C and DDIT3

Data Source:
BioGRID (two hybrid)

		VPS37C	DDIT3
Description		VPS37C subunit of ESCRT-I	DNA damage inducible transcript 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Host Cell Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Late Endosome Cytosol Protein-DNA Complex CHOP-C/EBP Complex CHOP-ATF4 Complex CHOP-ATF3 Complex
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Heterodimerization Activity Transcription Regulator Inhibitor Activity
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Endosomal Transport Macroautophagy Viral Life Cycle Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Of Virus	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Maturation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus ER Overload Response Response To Unfolded Protein Cell Cycle Arrest Sensory Perception Of Sound Anterior/posterior Axis Specification Regulation Of Autophagy Wnt Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-8 Production Negative Regulation Of CREB Transcription Factor Activity Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Response To Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases			Myxoid liposarcoma
GWAS		Periventricular white matter hyperintensities ( 32517579) Rheumatoid arthritis ( 23143596)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		102 interacting genes: AARD ABHD11 ABI2 APP ASCL3 BAG4 BIRC7 C1orf94 CBFA2T3 CEP55 CRX DAZAP2 DCTN3 DDIT3 DYDC1 EYA2 FAM168A FAM168B FCHSD2 FOXI1 FUBP1 GOLGA2 GPS2 GRB2 HAUS1 HELT HGS HNRNPF HNRNPUL1 HYI ILF3 KLF1 KRT27 KRT33B KRTAP15-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LAGE3 LASP1 MAPK1IP1L METTL27 NTAQ1 NUP54 NUTM2F P4HA3 PAX9 PDCD6 PDCD6IP PEF1 PKNOX1 PKNOX2 PLA2G10 PLEKHG4 PLSCR1 POLR2J POLR2J3 POU2AF1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RAMAC RBPMS RBPMS2 RFX6 RIBC1 RINT1 RPRD1B RUNX1 SH3GL1 SH3RF1 SH3RF2 SORBS2 SORBS3 SPAG8 STAM2 STH TACC3 TFAP2D TFG TFIP11 TIAL1 TLE5 TSC1 TSG101 UBAP2 UBC UFSP1 VPS28 WWOX WWP2 XIAP YTHDF1 ZMAT5 ZMYND12 ZNF34	68 interacting genes: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 CCDC153 CDK6 CEBPA CEBPB CEBPE CEBPG CRACR2A CREB3 CREB3L1 CREBL2 CSNK2A1 DBP DGCR2 DNMT3L EMSY EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIMAP6 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JDP2 JUN JUNB JUND KPNA2 LMO2 LNX1 MAFF MAFG MAPK14 MCMBP NFIL3 PCM1 PICALM POLR1D RAI1 RPS3 RPS3A SNAPC5 SPOP SRA1 SSX3 TEDC1 TNFSF12 TRIB3 TXN2 TXNDC2 VPS37C ZBTB25 ZC3H14 ZSCAN31
Entrez ID		55048	1649
HPRD ID		15652	00529
Ensembl ID		ENSG00000167987	ENSG00000175197
Uniprot IDs		A5D8V6	P35638 Q53YD1
PDB IDs
Enriched GO Terms of Interacting Partners?
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