UBE2H and TRIM56

Data Source:
BioGRID (two hybrid)

		UBE2H	TRIM56
Description		ubiquitin conjugating enzyme E2 H	tripartite motif containing 56
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GO Annotations	Cellular Component	Nucleus Cytosol	Chromatin Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Regulation Of Type I Interferon Production Interferon-beta Production Response To Type I Interferon Innate Immune Response Positive Regulation Of Transcription, DNA-templated Defense Response To Virus Protein K63-linked Ubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of innate immune responses to cytosolic DNA
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Alzheimer's disease ( 30636644) Nonunion in individuals with fractures ( 30680360)
Interacting Genes		68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3	4 interacting genes: MIR200C MIR25 MIR34B UBE2H
Entrez ID		7328	81844
HPRD ID		03052	10284
Ensembl ID		ENSG00000186591	ENSG00000169871
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q9BRZ2
PDB IDs		2Z5D	5JW7
Enriched GO Terms of Interacting Partners?
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