FZD4 and MAGI3

Data Source:
HPRD (two hybrid, in vivo)

		FZD4	MAGI3
Description		frizzled class receptor 4	membrane associated guanylate kinase, WW and PDZ domain containing 3
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Dendrite Clathrin-coated Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Glutamatergic Synapse	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction
	Molecular Function	Amyloid-beta Binding Cytokine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Cytokine Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Protein Homodimerization Activity Wnt-activated Receptor Activity Protein-containing Complex Binding Protein Heterodimerization Activity	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity
	Biological Process	Vasculogenesis G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Sensory Perception Of Sound Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Neuron Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Substrate Adhesion-dependent Cell Spreading Extracellular Matrix-cell Signaling Non-canonical Wnt Signaling Pathway Progesterone Secretion Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Retina Vasculature Morphogenesis In Camera-type Eye Cerebellum Vasculature Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway Norrin Signaling Pathway Positive Regulation Of Neuron Projection Arborization Cellular Response To Leukemia Inhibitory Factor	Apoptotic Process Signal Transduction Viral Process Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD4 Signaling by RNF43 mutants Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Hepatocellular carcinoma in hepatitis B infection ( 26870257)	Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		7 interacting genes: ARRB2 BAG6 DLG1 DLG2 DLG4 DVL2 MAGI3	16 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2
Entrez ID		8322	260425
HPRD ID		05203	11290
Ensembl ID		ENSG00000174804	ENSG00000081026
Uniprot IDs		Q9ULV1	Q5TCQ9
PDB IDs		5BPB 5BPQ 5BQC 5BQE 5CL1 5CM4 5UWG 6BD4 6NE1	3SOE
Enriched GO Terms of Interacting Partners?
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