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DYSF and PLP1
Data Source:
BioGRID
(two hybrid)
DYSF
PLP1
Description
dysferlin
proteolipid protein 1
Image
GO Annotations
Cellular Component
Endosome
Early Endosome
Late Endosome
Plasma Membrane
Integral Component Of Membrane
Endocytic Vesicle
T-tubule
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Centriolar Satellite
Sarcolemma
Extracellular Exosome
Plasma Membrane
Integrin Alphav-beta3 Complex
Myelin Sheath
Synapse
Molecular Function
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipid Binding
Structural Molecule Activity
Protein Binding
Structural Constituent Of Myelin Sheath
Biological Process
Plasma Membrane Repair
Monocyte Activation Involved In Immune Response
Macrophage Activation Involved In Immune Response
Vesicle Fusion
Muscle Contraction
Plasma Membrane Organization
T-tubule Organization
Negative Regulation Of Phagocytosis
Membrane Fusion
Inflammatory Response
Chemical Synaptic Transmission
Axon Ensheathment
Positive Regulation Of Gene Expression
Astrocyte Development
Substantia Nigra Development
Central Nervous System Myelination
Positive Regulation Of Cell Migration
Neuron Projection Development
Long-chain Fatty Acid Biosynthetic Process
Axon Development
AMPA Selective Glutamate Receptor Signaling Pathway
Positive Regulation Of Calcium Ion Transmembrane Transport
Pathways
Smooth Muscle Contraction
Smooth Muscle Contraction
Drugs
Diseases
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
Dysferlinopathies, including: Miyoshi myopathy (MM); Limb-girdle muscular dystrophy (LGMD) 2B; Distal myopathy with anterior tibial onset (DMAT)
Limb-girdle muscular dystrophy (LGMD)
Hereditary spastic paraplegia (SPG)
Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS
Asthma (
32296059
)
Extremely high intelligence (
29520040
)
General cognitive ability (
29844566
)
Hip circumference adjusted for BMI (
28552196
)
Nonalcoholic steatohepatitis-derived hepatocellular carcinoma (
29385134
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Protein quantitative trait loci (
18464913
)
Urate levels in overweight individuals (
25811787
)
Interacting Genes
40 interacting genes:
AKAP1
ANKRD1
ANXA1
ANXA2
APPL1
CAPN3
CAV3
CMYA5
COL12A1
COL6A3
DGKD
DHX15
DNAJB6
EEF1A1
EEF1G
FAM120A
GNL3
KARS1
KIF1B
MORF4L1
MYBPC1
MYBPC2
MYH3
MYOM1
MYOM2
NPHP3
OPTN
OS9
PHF1
PLP1
RNF10
RNF2
SAMHD1
SGCG
SLC12A6
SNAPIN
TAF1
XIRP2
XRCC6
ZNF23
86 interacting genes:
ADGRG3
AKT1
AQP10
AQP6
ARL13B
BCL2L13
BIK
CALN1
CALR
CANX
CD40
CD74
CDIPT
CLDN2
CLDN20
CLEC2D
CLN8
CREB3
CREB3L1
CYBC1
DCT
DYSF
EDA2R
ELOVL4
ERGIC3
FAM209A
FCRL2
FFAR2
FNDC9
GAST
GPR42
GPR61
HAS3
HTR2C
IER3IP1
IFITM3
ITGAV
JAGN1
JPH1
KLRC1
LEPROTL1
LEUTX
LHFPL5
LMNA
MAG
MBP
MFF
MGST3
MS4A3
MS4A4A
MTIF3
MUC1
MYADM
NRG1
PI16
PIGP
PTPRN
RELL2
RMDN3
RNF24
SLC10A6
SLC16A2
SLC18A1
SLC1A5
SLC26A6
SLC35E2A
SLC35E3
SLC41A3
SMIM3
SPNS3
STX1A
STX4
SUSD3
TMEM106C
TMEM14B
TMEM182
TMEM242
TMEM243
TMEM254
TMEM31
TMEM45B
TMEM52B
TMEM97
TMPRSS2
UPK2
VAT1
Entrez ID
8291
5354
HPRD ID
04307
02321
Ensembl ID
ENSG00000135636
ENSG00000123560
Uniprot IDs
O75923
A0A0S2Z4D4
A8K9L3
B4DI30
P60201
PDB IDs
4CAH
4CAI
4IHB
4IQH
2XPG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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