DYSF and MYOM1

Data Source:
BioGRID (affinity chromatography technology, two hybrid, imaging technique)

		DYSF	MYOM1
Description		dysferlin	myomesin 1
Image
GO Annotations	Cellular Component	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Membrane Endocytic Vesicle T-tubule Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Extracellular Exosome	Striated Muscle Myosin Thick Filament M Band
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	Protein Binding Structural Constituent Of Muscle Kinase Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding
	Biological Process	Plasma Membrane Repair Monocyte Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Vesicle Fusion Muscle Contraction Plasma Membrane Organization T-tubule Organization Negative Regulation Of Phagocytosis Membrane Fusion	Extraocular Skeletal Muscle Development Muscle Contraction Positive Regulation Of Gene Expression Protein Kinase A Signaling Positive Regulation Of Protein Secretion
Pathways		Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Dysferlinopathies, including: Miyoshi myopathy (MM); Limb-girdle muscular dystrophy (LGMD) 2B; Distal myopathy with anterior tibial onset (DMAT) Limb-girdle muscular dystrophy (LGMD)
GWAS		Asthma ( 32296059) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 28552196) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Protein quantitative trait loci ( 18464913) Urate levels in overweight individuals ( 25811787)	Brain volume in infants (white matter) ( 28763065) Night sleep phenotypes ( 27126917) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		40 interacting genes: AKAP1 ANKRD1 ANXA1 ANXA2 APPL1 CAPN3 CAV3 CMYA5 COL12A1 COL6A3 DGKD DHX15 DNAJB6 EEF1A1 EEF1G FAM120A GNL3 KARS1 KIF1B MORF4L1 MYBPC1 MYBPC2 MYH3 MYOM1 MYOM2 NPHP3 OPTN OS9 PHF1 PLP1 RNF10 RNF2 SAMHD1 SGCG SLC12A6 SNAPIN TAF1 XIRP2 XRCC6 ZNF23	16 interacting genes: ANKRD28 C1QTNF9 CLK1 DNAJB6 DYSF KRT31 KRTAP1-1 KRTAP5-7 MTUS2 MYH9 PDE4DIP PPP1R16A SYNE1 TFIP11 TRIM23 TTN
Entrez ID		8291	8736
HPRD ID		04307	04618
Ensembl ID		ENSG00000135636	ENSG00000101605
Uniprot IDs		O75923	P52179
PDB IDs		4CAH 4CAI 4IHB 4IQH	2R15 2Y23 2Y25 3RBS 5FM4 5FM5 5FM8
Enriched GO Terms of Interacting Partners?
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