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H3-4 and KAT2A
Data Source:
BioGRID
(unspecified method)
H3-4
KAT2A
Description
H3.4 histone
lysine acetyltransferase 2A
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Extracellular Exosome
Histone Acetyltransferase Complex
Extracellular Space
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Chromosome
Centrosome
STAGA Complex
Transcription Factor TFTC Complex
Oxoglutarate Dehydrogenase Complex
Mitotic Spindle
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Transcription Factor Binding
H3 Histone Acetyltransferase Activity
Protein Phosphatase Binding
Histone Deacetylase Binding
Histone Acetyltransferase Activity (H4-K12 Specific)
Peptide-lysine-N-acetyltransferase Activity
Histone Succinyltransferase Activity
Histone Glutaryltransferase Activity
Biological Process
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
Telomere Capping
In Utero Embryonic Development
Somitogenesis
Cytokine Production
Neural Tube Closure
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Heart Development
Long-term Memory
Cell Population Proliferation
Response To Organic Cyclic Compound
Viral Process
Histone Acetylation
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Telencephalon Development
Metencephalon Development
Midbrain Development
Positive Regulation Of Cell Projection Organization
Regulation Of Protein Stability
Response To Nutrient Levels
Positive Regulation Of Histone Acetylation
Multicellular Organism Growth
Histone H3 Acetylation
Histone H4-K12 Acetylation
Histone H3-K14 Acetylation
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Regulation Of Synaptic Plasticity
Intracellular Distribution Of Mitochondria
Regulation Of T Cell Activation
Limb Development
Regulation Of Cartilage Development
Cellular Response To Tumor Necrosis Factor
Alpha-tubulin Acetylation
Histone Succinylation
Peptidyl-lysine Glutarylation
Regulation Of Bone Development
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Meiotic recombination
Inhibition of DNA recombination at telomere
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Ub-specific processing proteases
RNA Polymerase I Transcription Initiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Coenzyme A
Diseases
GWAS
Coronary artery disease (
29212778
33020668
)
Inflammatory bowel disease (
26278503
)
Mean reticulocyte volume (
32888494
)
Vitiligo (
27723757
)
vWF and FVIII levels (
30586737
)
Interacting Genes
198 interacting genes:
ADNP
AFF1
AHDC1
ANP32A
ASF1A
ASH2L
ATAD2
AURKA
AURKB
BIRC5
BMI1
BPTF
BRD7
C17orf49
CBX1
CBX2
CBX3
CBX4
CBX5
CBX7
CBX8
CDYL
CDYL2
CHAF1A
CHAF1B
CHAMP1
CHD1
CHD4
CHD6
CHUK
COPRS
CREBBP
CTBP1
CTBP2
DCAF1
DEK
DIDO1
DNMT1
DOT1L
DPF2
DPY30
DYRK2
EGFR
EHMT1
EHMT2
EMSY
EP300
ERAP1
EZH2
FOXA1
GADD45A
GATAD1
GLYR1
GTF3C4
HAT1
HDAC1
HDAC2
HDAC8
HIRIP3
HMGXB4
HNRNPA1
HNRNPA2B1
HNRNPAB
HNRNPK
HNRNPL
HNRNPR
HPF1
ING2
ING4
IRAK1
JADE2
JADE3
JAK1
JAK2
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM1B
KDM2A
KDM3B
KDM5A
KDM5D
KDM6A
KIF2A
KIF2C
KMT2A
KMT2C
KPNA1
LRIF1
LRWD1
MBD3
MCM2
MCM7
MDM2
MEN1
MGA
MIER1
MLLT1
MORF4L1
MSL3
MTA1
MTA2
MYB
NAP1L4
NASP
NBN
NCL
NCOA2
NCOA3
NOC2L
NONO
NPM1
NSD1
NSD2
ORC2
ORC3
ORC4
ORC5
PARP1
PARP2
PCGF6
PHC2
PHC3
PHF12
PHF7
PHF8
PHRF1
PIM1
POGZ
PPIB
PPM1G
PRDM2
PRKCA
PRMT5
PTBP1
PTMA
RAG1
RBBP4
RBBP5
RBBP7
RBP5
RCOR1
RING1
RIPPLY1
RNF2
RPS6KA3
RPS6KA5
RREB1
SAP30
SET
SETD2
SETD7
SETDB1
SFPQ
SGF29
SIN3A
SIN3B
SMN1
SMNDC1
SMYD3
SUPT20H
SUPT3H
SUV39H1
SUZ12
TADA1
TADA3
TAF1
TAF10
TAF11
TAF12
TAF13
TAF15
TAF1A
TAF2
TAF3
TAF4
TAF4B
TAF5
TAF5L
TAF6
TAF6L
TAF7
TAF8
TAF9
TAF9B
TBP
TCF19
TDRD3
TNPO1
TRPM7
UHRF1
WDR5
ZMYM4
ZMYND11
ZNF217
ZNF516
60 interacting genes:
AKT1
ATXN7
BATF2
BECN1
CCND2
CCNE1
CDK2
CDK6
CDKN2B
CEBPB
COMMD1
CREBBP
CRX
CTNNB1
CUL2
DTL
EID1
EP300
FZR1
GATA2
GRM1
H1-5
H2AC20
H2BC21
H3-4
H3C14
H4-16
H4C14
HSD11B2
IRF1
IRF2
IRF7
KDELR2
LATS2
MAP2K3
MAPK14
MYB
MYC
NF2
NOTCH1
PBX1
PPARG
PRKDC
PYGO2
RASSF1
RBPJ
RELA
SIRT2
STK11
TACC1
TACC2
TACC3
TADA2A
TCF3
TP53
TRRAP
TSC1
TTYH2
UBE2I
XRCC6
Entrez ID
8290
2648
HPRD ID
04156
03807
Ensembl ID
ENSG00000168148
ENSG00000108773
Uniprot IDs
Q16695
Q92830
PDB IDs
2V1D
2YBP
2YBS
3A6N
3T6R
4V2V
4V2W
6OIE
6WAT
6WAU
1F68
1Z4R
3D7C
5H84
5H86
5MLJ
5TRL
5TRM
6J3P
Enriched GO Terms of Interacting Partners
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