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H3-4 and PARP1
Data Source:
BioGRID
(enzymatic study)
H3-4
PARP1
Description
H3.4 histone
poly(ADP-ribose) polymerase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Extracellular Exosome
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Mitochondrion
Membrane
Nuclear Body
Protein-containing Complex
Protein-DNA Complex
Site Of Double-strand Break
Site Of DNA Damage
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
DNA Binding
RNA Binding
NAD+ ADP-ribosyltransferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Estrogen Receptor Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein N-terminus Binding
NAD Binding
R-SMAD Binding
NAD DNA ADP-ribosyltransferase Activity
Protein ADP-ribosylase Activity
Biological Process
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
Telomere Capping
Negative Regulation Of Transcription By RNA Polymerase II
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Double-strand Break Repair
Transcription By RNA Polymerase II
Protein ADP-ribosylation
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Mitochondrion Organization
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Gamma Radiation
Positive Regulation Of Cardiac Muscle Hypertrophy
Regulation Of SMAD Protein Complex Assembly
Protein Autoprocessing
Peptidyl-serine ADP-ribosylation
Peptidyl-glutamic Acid Poly-ADP-ribosylation
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
DNA ADP-ribosylation
Mitochondrial DNA Metabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Nucleotide-excision Repair, DNA Incision
Cellular Response To Oxidative Stress
Cellular Response To UV
Protein Modification Process
DNA Damage Response, Detection Of DNA Damage
Mitochondrial DNA Repair
Regulation Of DNA Methylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Catalytic Activity
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of SMAD Protein Signal Transduction
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Global Genome Nucleotide-excision Repair
Cellular Response To Zinc Ion
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Neuron Death
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Single Strand Break Repair
Regulation Of Cellular Protein Localization
Response To Aldosterone
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cellular Response To Amyloid-beta
Positive Regulation Of Myofibroblast Differentiation
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
ATP Generation From Poly-ADP-D-ribose
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of ATP Biosynthetic Process
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Meiotic recombination
Inhibition of DNA recombination at telomere
POLB-Dependent Long Patch Base Excision Repair
vRNA Synthesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Drugs
Theophylline
Zinc
Carba-nicotinamide-adenine-dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
Veliparib
A-620223
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Olaparib
Talazoparib
Niraparib
Rucaparib
Iniparib
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Coronary artery disease (
29212778
)
Leukocyte telomere length (
32109421
31171785
)
Melanoma (
21983785
)
Mild to moderate chronic kidney disease (
31178898
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Platelet count (
29403010
)
Telomere length (
29151059
)
Interacting Genes
198 interacting genes:
ADNP
AFF1
AHDC1
ANP32A
ASF1A
ASH2L
ATAD2
AURKA
AURKB
BIRC5
BMI1
BPTF
BRD7
C17orf49
CBX1
CBX2
CBX3
CBX4
CBX5
CBX7
CBX8
CDYL
CDYL2
CHAF1A
CHAF1B
CHAMP1
CHD1
CHD4
CHD6
CHUK
COPRS
CREBBP
CTBP1
CTBP2
DCAF1
DEK
DIDO1
DNMT1
DOT1L
DPF2
DPY30
DYRK2
EGFR
EHMT1
EHMT2
EMSY
EP300
ERAP1
EZH2
FOXA1
GADD45A
GATAD1
GLYR1
GTF3C4
HAT1
HDAC1
HDAC2
HDAC8
HIRIP3
HMGXB4
HNRNPA1
HNRNPA2B1
HNRNPAB
HNRNPK
HNRNPL
HNRNPR
HPF1
ING2
ING4
IRAK1
JADE2
JADE3
JAK1
JAK2
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM1B
KDM2A
KDM3B
KDM5A
KDM5D
KDM6A
KIF2A
KIF2C
KMT2A
KMT2C
KPNA1
LRIF1
LRWD1
MBD3
MCM2
MCM7
MDM2
MEN1
MGA
MIER1
MLLT1
MORF4L1
MSL3
MTA1
MTA2
MYB
NAP1L4
NASP
NBN
NCL
NCOA2
NCOA3
NOC2L
NONO
NPM1
NSD1
NSD2
ORC2
ORC3
ORC4
ORC5
PARP1
PARP2
PCGF6
PHC2
PHC3
PHF12
PHF7
PHF8
PHRF1
PIM1
POGZ
PPIB
PPM1G
PRDM2
PRKCA
PRMT5
PTBP1
PTMA
RAG1
RBBP4
RBBP5
RBBP7
RBP5
RCOR1
RING1
RIPPLY1
RNF2
RPS6KA3
RPS6KA5
RREB1
SAP30
SET
SETD2
SETD7
SETDB1
SFPQ
SGF29
SIN3A
SIN3B
SMN1
SMNDC1
SMYD3
SUPT20H
SUPT3H
SUV39H1
SUZ12
TADA1
TADA3
TAF1
TAF10
TAF11
TAF12
TAF13
TAF15
TAF1A
TAF2
TAF3
TAF4
TAF4B
TAF5
TAF5L
TAF6
TAF6L
TAF7
TAF8
TAF9
TAF9B
TBP
TCF19
TDRD3
TNPO1
TRPM7
UHRF1
WDR5
ZMYM4
ZMYND11
ZNF217
ZNF516
105 interacting genes:
APTX
ATM
BCL2
BLID
BRD7
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CENPA
CENPB
CREBBP
CTCF
CTSB
CTSG
DTX2
DUX4
E2F1
ERCC6
ERG
ETS1
FOXO1
GTF2F1
GZMB
GZMM
H1-0
H1-1
H1-2
H1-5
H2AC18
H2BC4
H3-3A
H3-4
H3C1
H4C3
HDAC1
HDAC3
HIPK2
HMGA1
HMGN1
HMGN2
HMGN4
HOXB7
HPF1
HSPA2
IKBKG
IL24
KAT2B
KLF5
LIG3
LZTR1
MACROH2A1
MED14
MED6
MORC2
MTA3
MYBL2
NAT10
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
OVOL2
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POU2F1
PRKDC
RARA
RASL10B
RBM14
RELA
RNF144A
RNF168
RPS3A
RXRA
SENP1
SENP3
SIRT1
SP1
SREK1
SUMO2
SUPT16H
SWAP70
TCF3
TCF4
THRSP
TP53
UBE2I
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
Entrez ID
8290
142
HPRD ID
04156
01435
Ensembl ID
ENSG00000168148
ENSG00000143799
Uniprot IDs
Q16695
A0A024R3T8
P09874
PDB IDs
2V1D
2YBP
2YBS
3A6N
3T6R
4V2V
4V2W
6OIE
6WAT
6WAU
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2N8A
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
4OPX
4OQA
4OQB
4PJT
4R5W
4R6E
4RV6
4UND
4UXB
4XHU
4ZZZ
5A00
5DS3
5HA9
5KPN
5KPO
5KPP
5KPQ
5WRQ
5WRY
5WRZ
5WS0
5WS1
5WTC
5XSR
5XST
5XSU
6BHV
6GHK
6NRF
6NRG
6NRH
6NRI
6NRJ
6NTU
6VKK
6VKO
6VKQ
6XVW
Enriched GO Terms of Interacting Partners
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