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H3-4 and WDR5
Data Source:
BioGRID
(pull down)
H3-4
WDR5
Description
H3.4 histone
WD repeat domain 5
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Extracellular Exosome
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Histone Methyltransferase Complex
MLL3/4 Complex
Set1C/COMPASS Complex
MLL1 Complex
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Protein Binding
Methylated Histone Binding
Histone Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Biological Process
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
Telomere Capping
Skeletal System Development
Neuron Projection Development
Post-translational Protein Modification
Histone H3 Acetylation
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Gluconeogenesis
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K4 Methylation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Meiotic recombination
Inhibition of DNA recombination at telomere
PKMTs methylate histone lysines
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Neddylation
Drugs
Diseases
GWAS
Cerebrospinal fluid t-tau levels in normal cognition (
29274321
)
Intraocular pressure (
30591961
)
Interacting Genes
198 interacting genes:
ADNP
AFF1
AHDC1
ANP32A
ASF1A
ASH2L
ATAD2
AURKA
AURKB
BIRC5
BMI1
BPTF
BRD7
C17orf49
CBX1
CBX2
CBX3
CBX4
CBX5
CBX7
CBX8
CDYL
CDYL2
CHAF1A
CHAF1B
CHAMP1
CHD1
CHD4
CHD6
CHUK
COPRS
CREBBP
CTBP1
CTBP2
DCAF1
DEK
DIDO1
DNMT1
DOT1L
DPF2
DPY30
DYRK2
EGFR
EHMT1
EHMT2
EMSY
EP300
ERAP1
EZH2
FOXA1
GADD45A
GATAD1
GLYR1
GTF3C4
HAT1
HDAC1
HDAC2
HDAC8
HIRIP3
HMGXB4
HNRNPA1
HNRNPA2B1
HNRNPAB
HNRNPK
HNRNPL
HNRNPR
HPF1
ING2
ING4
IRAK1
JADE2
JADE3
JAK1
JAK2
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM1B
KDM2A
KDM3B
KDM5A
KDM5D
KDM6A
KIF2A
KIF2C
KMT2A
KMT2C
KPNA1
LRIF1
LRWD1
MBD3
MCM2
MCM7
MDM2
MEN1
MGA
MIER1
MLLT1
MORF4L1
MSL3
MTA1
MTA2
MYB
NAP1L4
NASP
NBN
NCL
NCOA2
NCOA3
NOC2L
NONO
NPM1
NSD1
NSD2
ORC2
ORC3
ORC4
ORC5
PARP1
PARP2
PCGF6
PHC2
PHC3
PHF12
PHF7
PHF8
PHRF1
PIM1
POGZ
PPIB
PPM1G
PRDM2
PRKCA
PRMT5
PTBP1
PTMA
RAG1
RBBP4
RBBP5
RBBP7
RBP5
RCOR1
RING1
RIPPLY1
RNF2
RPS6KA3
RPS6KA5
RREB1
SAP30
SET
SETD2
SETD7
SETDB1
SFPQ
SGF29
SIN3A
SIN3B
SMN1
SMNDC1
SMYD3
SUPT20H
SUPT3H
SUV39H1
SUZ12
TADA1
TADA3
TAF1
TAF10
TAF11
TAF12
TAF13
TAF15
TAF1A
TAF2
TAF3
TAF4
TAF4B
TAF5
TAF5L
TAF6
TAF6L
TAF7
TAF8
TAF9
TAF9B
TBP
TCF19
TDRD3
TNPO1
TRPM7
UHRF1
WDR5
ZMYM4
ZMYND11
ZNF217
ZNF516
37 interacting genes:
ANAPC2
APP
ASH2L
ATN1
BBC3
BHLHE41
CHD8
FAM199X
H1-2
H3-4
H3C1
H4-16
HSF2
IKBKG
KANSL1
KANSL2
KMT2A
MARF1
MBIP
MDM4
MEOX2
MLLT1
NR2E3
PDE9A
POU5F1
PRMT5
PRNP
RBBP5
RUSC1-AS1
SRPK2
SRRM4
SSX2IP
TERF2IP
TP53
WWP2
ZBTB48
ZXDC
Entrez ID
8290
11091
HPRD ID
04156
10614
Ensembl ID
ENSG00000168148
ENSG00000196363
Uniprot IDs
Q16695
P61964
PDB IDs
2V1D
2YBP
2YBS
3A6N
3T6R
4V2V
4V2W
6OIE
6WAT
6WAU
2CNX
2CO0
2G99
2G9A
2GNQ
2H13
2H14
2H68
2H6K
2H6N
2H6Q
2H9L
2H9M
2H9N
2H9P
2O9K
3EG6
3EMH
3MXX
3N0D
3N0E
3P4F
3PSL
3SMR
3UR4
3UVK
3UVL
3UVM
3UVN
3UVO
4A7J
4CY1
4CY2
4ERQ
4ERY
4ERZ
4ES0
4ESG
4EWR
4GM3
4GM8
4GM9
4GMB
4IA9
4O45
4QL1
4Y7R
5EAL
5EAM
5EAP
5EAR
5M23
5M25
5SXM
5VFC
6BYN
6D9X
6DAI
6DAK
6DAR
6DAS
6DY7
6DYA
6E1Y
6E1Z
6E22
6E23
6IAM
6KIU
6KIV
6KIW
6KIX
6KIZ
6OFZ
6OI0
6OI1
6OI2
6OI3
6PG3
6PG4
6PG5
6PG6
6PG7
6PG8
6PG9
6PGA
6PGB
6PGC
6PGD
6PGE
6PGF
6PWV
6PWW
6U5M
6U5Y
6U6W
6U80
6U8B
6U8L
6U8O
6UCS
6UFX
6UHY
6UHZ
6UIF
6UIK
6UJ4
6UJH
6UJJ
6UJL
6UOZ
Enriched GO Terms of Interacting Partners
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