CAPNS1 and GNB2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CAPNS1	GNB2
Description		calpain small subunit 1	G protein subunit beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Extracellular Exosome	Extracellular Space Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Vesicle Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	GTPase Activity Calcium Channel Regulator Activity Protein Binding G-protein Gamma-subunit Binding Protein-containing Complex Binding GTPase Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Cornification	Protein Folding G Protein-coupled Receptor Signaling Pathway
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		PD150606
Diseases
GWAS			Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)
Interacting Genes		20 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5	33 interacting genes: ANXA7 ATXN10 CAPNS1 CDKN1A CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 GRK2 GSK3B ID3 MTNR1B NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1
Entrez ID		826	2783
HPRD ID		00240	11820
Ensembl ID		ENSG00000126247	ENSG00000172354
Uniprot IDs		A0A0C4DGQ5 P04632	P62879 Q6FHM2
PDB IDs		1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB
Enriched GO Terms of Interacting Partners?
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