CAPNS1 and CAST

Data Source:
HPRD (in vitro)

		CAPNS1	CAST
Description		calpain small subunit 1	calpastatin
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	RNA Binding Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cadherin Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Cornification	Inhibition Of Cysteine-type Endopeptidase Activity Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		PD150606	Calcium Artenimol
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Blood protein levels ( 28240269) Body mass index ( 29381148 26426971) Fish- and plant-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		20 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5	11 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 SUMO2
Entrez ID		826	831
HPRD ID		00240	00233
Ensembl ID		ENSG00000126247	ENSG00000153113
Uniprot IDs		A0A0C4DGQ5 P04632	B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9
PDB IDs		1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB
Enriched GO Terms of Interacting Partners?
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