NDUFB7 and CAPN1

Data Source:
BioGRID (two hybrid)

		NDUFB7	CAPN1
Description		NADH:ubiquinone oxidoreductase subunit B7	calpain 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Respiratory Chain Complex I Assembly	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity
Pathways		Respiratory electron transport Complex I biogenesis	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		NADH	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS			Urate levels ( 31578528)
Interacting Genes		41 interacting genes: AGBL2 ANKRD36B ATG9A C1orf109 CAPN1 CCDC24 CCNC CDCA7L CDKN2D CHIC2 CINP CKAP4 CTNNA3 ENKD1 FAM161B FAM90A1 GEM GPATCH2L GYS1 KRTAP10-10 LMO2 MAGOHB MAK MEIS2 MKRN3 MLKL NDUFB2 NFKBIB NFKBID RCOR3 RECK RIPPLY1 RIPPLY2 SCNM1 SPRED2 STRA6 TLE5 ZNF330 ZNF417 ZNF564 ZNF587	54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		4713	823
HPRD ID		11957	00253
Ensembl ID		ENSG00000099795	ENSG00000014216
Uniprot IDs		P17568	B2RDI5 B4DWH5 P07384
PDB IDs		5XTC 5XTD 5XTH 5XTI	1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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