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IL1A and KPNA6
Data Source:
BioGRID
(two hybrid)
IL1A
KPNA6
Description
interleukin 1 alpha
karyopherin subunit alpha 6
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Host Cell
Molecular Function
Cytokine Activity
Interleukin-1 Receptor Binding
Copper Ion Binding
Protein Binding
Protein Binding
Nuclear Localization Sequence Binding
Nuclear Import Signal Receptor Activity
Biological Process
Fever Generation
Positive Regulation Of Cytokine Production
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Cellular Sodium Ion Homeostasis
Apoptotic Process
Inflammatory Response
Immune Response
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Immature T Cell Proliferation In Thymus
Cellular Response To Heat
Ectopic Germ Cell Programmed Cell Death
Positive Regulation Of Angiogenesis
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Response To Copper Ion
Positive Regulation Of Protein Secretion
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Cell Division
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
NLS-bearing Protein Import Into Nucleus
Viral Genome Replication
Mitigation Of Host Defenses By Symbiont
Positive Regulation Of Transcription By RNA Polymerase II
Maternal Process Involved In Female Pregnancy
Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Viral Life Cycle
Pathways
Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 processing
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling
Purinergic signaling in leishmaniasis infection
Drugs
Rilonacept
Diseases
Graft-versus-host disease
GWAS
Dysmenorrheic pain severity (
29855537
)
Endometriosis (
20844546
28537267
)
Gestational age at birth (child effect) (
31477735
)
Interleukin-1-receptor antagonist levels (
22205395
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Post-term birth (
31477735
)
Response to antipsychotic treatment in schizophrenia (working memory) (
21107309
)
Body mass index (
26426971
)
Interacting Genes
11 interacting genes:
CAPN1
CASP1
HAX1
IL1R1
IL1R2
IL1RAP
KPNA6
MEOX2
NDN
NFKBIE
S100A13
37 interacting genes:
ANKRD11
ANP32A
ANP32B
ARNT
BRCA1
CDKN1B
CREBBP
CSE1L
DCPS
EPAS1
FAM90A1
FRG1BP
GEMIN2
HIF1A
IL1A
JRK
KAT5
KEAP1
KPNB1
LMNA
LMNB1
MAGED1
NMNAT1
NOP2
NUP50
POLR3C
POM121
POU6F2
RAC1
RELB
RNMT
SKP2
SMARCB1
STAT1
STAT3
TAF9
ZNF131
Entrez ID
3552
23633
HPRD ID
00988
09465
Ensembl ID
ENSG00000115008
ENSG00000025800
Uniprot IDs
P01583
O60684
PDB IDs
1ITA
2ILA
2KKI
2L5X
5UC6
4UAD
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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