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IL1A and CASP1
Data Source:
HPRD
(in vivo)
IL1A
CASP1
Description
interleukin 1 alpha
caspase 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Extracellular Region
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Protein-containing Complex
IPAF Inflammasome Complex
NLRP1 Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Protease Inhibitor Complex
Molecular Function
Cytokine Activity
Interleukin-1 Receptor Binding
Copper Ion Binding
Protein Binding
Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Kinase Binding
Identical Protein Binding
CARD Domain Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Fever Generation
Positive Regulation Of Cytokine Production
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Cellular Sodium Ion Homeostasis
Apoptotic Process
Inflammatory Response
Immune Response
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Immature T Cell Proliferation In Thymus
Cellular Response To Heat
Ectopic Germ Cell Programmed Cell Death
Positive Regulation Of Angiogenesis
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Response To Copper Ion
Positive Regulation Of Protein Secretion
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Cell Division
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Response To Hypoxia
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Regulation Of Autophagy
Protein Autoprocessing
Cytokine-mediated Signaling Pathway
Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Alpha Production
Positive Regulation Of Interleukin-1 Beta Production
Response To ATP
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Inflammatory Response
Mitochondrial Depolarization
Membrane Hyperpolarization
Pyroptosis
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Substance
Cellular Response To Cytokine Stimulus
Cellular Response To Interferon-gamma
Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Programmed Necrotic Cell Death
Signaling Receptor Ligand Precursor Processing
Toxin Transport
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways
Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 processing
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling
Purinergic signaling in leishmaniasis infection
NOD1/2 Signaling Pathway
Interleukin-1 processing
TP53 Regulates Transcription of Caspase Activators and Caspases
The NLRP3 inflammasome
The AIM2 inflammasome
The IPAF inflammasome
Interleukin-37 signaling
Purinergic signaling in leishmaniasis infection
Drugs
Rilonacept
Acetylsalicylic acid
Minocycline
Pralnacasan
LAX-101
Emricasan
VX-765
1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
Z-Val-Ala-Asp fluoromethyl ketone
3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
Graft-versus-host disease
GWAS
Dysmenorrheic pain severity (
29855537
)
Endometriosis (
20844546
28537267
)
Gestational age at birth (child effect) (
31477735
)
Interleukin-1-receptor antagonist levels (
22205395
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Post-term birth (
31477735
)
Response to antipsychotic treatment in schizophrenia (working memory) (
21107309
)
Hip circumference adjusted for BMI (
28552196
)
Interacting Genes
11 interacting genes:
CAPN1
CASP1
HAX1
IL1R1
IL1R2
IL1RAP
KPNA6
MEOX2
NDN
NFKBIE
S100A13
42 interacting genes:
AR
ATN1
ATXN3
BCAP31
BCL2L1
BID
CARD16
CARD17
CARD8
CASP10
CASP14
CASP8
CAST
CDK11B
EGFR
FGF2
HTT
IL18
IL1A
IL1B
IL33
IL37
LMNA
MAPT
NEDD4
NFE2L2
NLRC4
NLRP1
NOD1
PAK1
PARP1
PLA2G4A
PLA2G4B
PRKN
PSEN1
PSEN2
PYCARD
RIPK2
SERPINB9
TFAP2A
TIRAP
VAC14
Entrez ID
3552
834
HPRD ID
00988
00977
Ensembl ID
ENSG00000115008
ENSG00000137752
Uniprot IDs
P01583
A8K249
A8K257
P29466
PDB IDs
1ITA
2ILA
2KKI
2L5X
5UC6
1BMQ
1IBC
1ICE
1RWK
1RWM
1RWN
1RWO
1RWP
1RWV
1RWW
1RWX
1SC1
1SC3
1SC4
2FQQ
2H48
2H4W
2H4Y
2H51
2H54
2HBQ
2HBR
2HBY
2HBZ
3D6F
3D6H
3D6M
3E4C
3NS7
5FNA
5MMV
5MTK
6BZ9
6F6R
6KN0
6PZP
6VIE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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