NDEL1 and KIF5A

Data Source:
BioGRID (two hybrid)

		NDEL1	KIF5A
Description		nudE neurodevelopment protein 1 like 1	kinesin family member 5A
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Centrosome Spindle Cytosol Kinesin Complex Microtubule Synaptic Vesicle Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Central Region Of Growth Cone Axon Cytoplasm	Cytosol Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Perikaryon Synapse Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding Oligopeptidase Activity	Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Activation Of GTPase Activity Positive Regulation Of Ruffle Assembly Neuron Projection Extension Regulation Of Microtubule Motor Activity	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoskeleton-dependent Intracellular Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS			Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 24449572 18794853) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		88 interacting genes: ABI3 ACTB AIMP2 AKAP9 ANK2 APP BMI1 BORCS6 BRK1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNC1I1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 KRT40 LUC7L2 MAGEA11 MBIP MED11 MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PARVG PICK1 PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TRIM27 TUBB USP2 XPA YWHAE YWHAG ZC2HC1C ZNF10 ZNF12 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF250 ZNF260 ZNF264 ZNF3 ZNF35 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF662 ZNF707 ZNF844 ZNF91	18 interacting genes: DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 NCOA2 NDEL1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSG101 YAP1
Entrez ID		81565	3798
HPRD ID		06340	09108
Ensembl ID		ENSG00000166579	ENSG00000155980
Uniprot IDs		A6NIZ0 Q9GZM8	Q12840
PDB IDs		2V66	4UXT 4UXY 4UY0
Enriched GO Terms of Interacting Partners?
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