KIF5A and KCNE3

Data Source:
BioGRID (two hybrid)

		KIF5A	KCNE3
Description		kinesin family member 5A	potassium voltage-gated channel subfamily E regulatory subunit 3
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GO Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Perikaryon Synapse Perinuclear Region Of Cytoplasm Axon Cytoplasm	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Vesicle Neuronal Cell Body Membrane Perikaryon Membrane Raft
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoskeleton-dependent Intracellular Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs			Enflurane Promethazine Miconazole
Diseases		Hereditary spastic paraplegia (SPG)	Brugada syndrome (BRS)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 24449572 18794853) Smoking initiation (ever regular vs never regular) ( 30679032)	Corneal astigmatism ( 22144915) Neuritic plaque ( 31497858)
Interacting Genes		18 interacting genes: DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 NCOA2 NDEL1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSG101 YAP1	10 interacting genes: C11orf68 EEF1A1 GAPDH GOLM1 KIF5A LRIF1 POLA2 QARS1 RASSF1 SLC44A1
Entrez ID		3798	10008
HPRD ID		09108	07256
Ensembl ID		ENSG00000155980	ENSG00000175538
Uniprot IDs		Q12840	Q6IAE6 Q9Y6H6
PDB IDs		4UXT 4UXY 4UY0	2NDJ 6V00 6V01
Enriched GO Terms of Interacting Partners?
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