FBXO38 and ABL2

Data Source:
BioGRID (two hybrid)

		FBXO38	ABL2
Description		F-box protein 38	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Cytosol Actin Cytoskeleton
	Molecular Function	Protein Binding	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Adaptive Immune Response Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Neuron Projection Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways			Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Negative regulation of FLT3
Drugs			ATP Dasatinib XL228 K-00546 Fostamatinib
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Lung function (FEV1/FVC) ( 31453325) Lung function (FEV1/FVC) variance ( 31453325) Mean reticulocyte volume ( 32888494) Periodontal microbiota ( 22699663) Zinc levels ( 26025379)	IgE grass sensitization ( 22036096)
Interacting Genes		8 interacting genes: ABL2 APP CREBBP KLF7 PPM1G RING1 SOX30 SUMO2	34 interacting genes: ABI2 ABL1 AR BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1
Entrez ID		81545	27
HPRD ID		09775	01259
Ensembl ID		ENSG00000145868	ENSG00000143322
Uniprot IDs		Q6AZE0 Q6PIJ6	P42684
PDB IDs			2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?
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