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ABL2 and EPHB2
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
ABL2
EPHB2
Description
ABL proto-oncogene 2, non-receptor tyrosine kinase
EPH receptor B2
Image
GO Annotations
Cellular Component
Cytosol
Actin Cytoskeleton
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Axon
Dendrite
Neuron Projection
Neuronal Cell Body
Receptor Complex
Postsynapse
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Molecular Function
Magnesium Ion Binding
Phosphotyrosine Residue Binding
Actin Monomer Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Manganese Ion Binding
Actin Filament Binding
Amyloid-beta Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane-ephrin Receptor Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Axon Guidance Receptor Activity
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Cellular Protein Modification Process
Cell Adhesion
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Autophagy
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Negative Regulation Of Rho Protein Signal Transduction
Exploration Behavior
Positive Regulation Of Oxidoreductase Activity
Cellular Response To Retinoic Acid
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
Angiogenesis
Urogenital System Development
Negative Regulation Of Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Nervous System Development
Axon Guidance
Axonal Fasciculation
Learning Or Memory
Learning
Positive Regulation Of Gene Expression
Phosphorylation
Peptidyl-tyrosine Phosphorylation
Optic Nerve Morphogenesis
Central Nervous System Projection Neuron Axonogenesis
Corpus Callosum Development
Regulation Of Blood Coagulation
Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Synaptic Plasticity
Positive Regulation Of Kinase Activity
Inner Ear Morphogenesis
Negative Regulation Of Ras Protein Signal Transduction
Ephrin Receptor Signaling Pathway
Regulation Of Neuronal Synaptic Plasticity
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Camera-type Eye Morphogenesis
Negative Regulation Of Axonogenesis
Regulation Of Body Fluid Levels
Inactivation Of MAPKK Activity
Positive Regulation Of Synapse Assembly
Roof Of Mouth Development
Dendritic Spine Development
Dendritic Spine Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Commissural Neuron Axon Guidance
Postsynaptic Membrane Assembly
Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission
Neuron Projection Retraction
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of NMDA Glutamate Receptor Activity
Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Negative regulation of FLT3
EPH-Ephrin signaling
EPH-Ephrin signaling
L1CAM interactions
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Drugs
ATP
Dasatinib
XL228
K-00546
Fostamatinib
Phosphoaminophosphonic Acid-Adenylate Ester
Fostamatinib
Diseases
GWAS
IgE grass sensitization (
22036096
)
Blood protein levels (
30072576
29875488
28240269
)
Refractive error (
32231278
)
Triiodothyronine levels (
30843173
)
Triiodothyronine levels and thyroxine levels (
30843173
)
Interacting Genes
34 interacting genes:
ABI2
ABL1
AR
BCR
C15orf48
CAT
CRK
DOK1
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FBXO38
GPX1
GRB2
HCK
KIT
MAP3K10
MDM2
MET
NEDD4
NEDD4L
OIP5
PDGFRB
PIK3R3
PSMA7
RIN1
SIVA1
SORBS2
STAT3
TPD52L1
TRIP10
ZMAT1
39 interacting genes:
ABL1
ABL2
ACP1
AFDN
AQP1
ARHGEF6
CRK
EFNA5
EFNB1
EFNB2
ERBB2
ERF
FBXO7
FOS
GRB2
GRIN1
GRIN2B
ITSN1
KALRN
KSR1
MMP2
MMP9
MTMR14
NCK1
PICK1
PLCG1
PTK2
RASA1
RRAS
RYK
SDC2
SDCBP
SH2D3C
SRC
SYNJ1
TRIM54
VAV2
VEGFA
YES1
Entrez ID
27
2048
HPRD ID
01259
02997
Ensembl ID
ENSG00000143322
ENSG00000133216
Uniprot IDs
P42684
B4DSE0
P29323
Q4LE53
Q6NVW1
PDB IDs
2ECD
2KK1
2XYN
3GVU
3HMI
3ULR
4EIH
5NP3
5NP5
1B4F
1F0M
2QBX
3ZFM
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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