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ABL2 and PSMA7
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
ABL2
PSMA7
Description
ABL proto-oncogene 2, non-receptor tyrosine kinase
proteasome 20S subunit alpha 7
Image
GO Annotations
Cellular Component
Cytosol
Actin Cytoskeleton
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Postsynapse
Molecular Function
Magnesium Ion Binding
Phosphotyrosine Residue Binding
Actin Monomer Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Manganese Ion Binding
Actin Filament Binding
Endopeptidase Activity
Protein Binding
Identical Protein Binding
Biological Process
Cellular Protein Modification Process
Cell Adhesion
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Autophagy
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Negative Regulation Of Rho Protein Signal Transduction
Exploration Behavior
Positive Regulation Of Oxidoreductase Activity
Cellular Response To Retinoic Acid
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Negative regulation of FLT3
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
ATP
Dasatinib
XL228
K-00546
Fostamatinib
acetylleucyl-leucyl-norleucinal
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
IgE grass sensitization (
22036096
)
Interacting Genes
34 interacting genes:
ABI2
ABL1
AR
BCR
C15orf48
CAT
CRK
DOK1
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FBXO38
GPX1
GRB2
HCK
KIT
MAP3K10
MDM2
MET
NEDD4
NEDD4L
OIP5
PDGFRB
PIK3R3
PSMA7
RIN1
SIVA1
SORBS2
STAT3
TPD52L1
TRIP10
ZMAT1
26 interacting genes:
ABL2
APP
BARD1
BRCA1
CAPN10
EGFR
EPM2AIP1
ERRFI1
HIF1A
INSIG1
INSIG2
OXTR
PLK1
PRKN
PSMA1
PSMA2
PSMA3
PSMA4
PSMA5
PSMA6
PSMC1
PSMF1
TBXA2R
TSC22D2
VCP
YOD1
Entrez ID
27
5688
HPRD ID
01259
05967
Ensembl ID
ENSG00000143322
ENSG00000101182
Uniprot IDs
P42684
A0A0K0K1K4
O14818
PDB IDs
2ECD
2KK1
2XYN
3GVU
3HMI
3ULR
4EIH
5NP3
5NP5
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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