SETD7 and STEAP3

Data Source:
BioGRID (two hybrid)

		SETD7	STEAP3
Description		SET domain containing 7, histone lysine methyltransferase	STEAP3 metalloreductase
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus	Cytoplasm Endosome Multivesicular Body Plasma Membrane Endosome Membrane Integral Component Of Membrane
	Molecular Function	P53 Binding Chromatin Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity	Protein Binding Cupric Reductase Activity Metal Ion Binding Ferric-chelate Reductase (NADPH) Activity
	Biological Process	Chromatin Organization Cellular Response To DNA Damage Stimulus Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Response To Ethanol Positive Regulation Of Transcription, DNA-templated Regulation Of Histone H3-K9 Methylation Heterochromatin Organization	Apoptotic Process Cell Cycle Protein Secretion Copper Ion Import Transferrin Transport Regulation Of Apoptotic Process Iron Ion Homeostasis
Pathways		PKMTs methylate histone lysines	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Transferrin endocytosis and recycling
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)	Cocaine dependence ( 23958962) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Renal cell carcinoma x sex interaction ( 31231134)
Interacting Genes		29 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21	6 interacting genes: BAD BNIP3L MTDH PKMYT1 SETD7 TPT1
Entrez ID		80854	55240
HPRD ID		16226	10285
Ensembl ID		ENSG00000145391	ENSG00000115107
Uniprot IDs		B5MCZ8 D6RJA0 Q8WTS6	A1P3F0 B8ZZX6 Q658P3
PDB IDs		1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT	2VNS 2VQ3
Enriched GO Terms of Interacting Partners?
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