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STEAP3 and BAD
Data Source:
BioGRID
(two hybrid)
STEAP3
BAD
Description
STEAP3 metalloreductase
BCL2 associated agonist of cell death
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Multivesicular Body
Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Molecular Function
Protein Binding
Cupric Reductase Activity
Metal Ion Binding
Ferric-chelate Reductase (NADPH) Activity
Protein Binding
Phospholipid Binding
Lipid Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Protein Kinase Binding
Protein Phosphatase Binding
Protein Phosphatase 2B Binding
Protein Kinase B Binding
14-3-3 Protein Binding
Biological Process
Apoptotic Process
Cell Cycle
Protein Secretion
Copper Ion Import
Transferrin Transport
Regulation Of Apoptotic Process
Iron Ion Homeostasis
Release Of Cytochrome C From Mitochondria
Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Glucose Catabolic Process
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Spermatogenesis
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Glucose
Positive Regulation Of Autophagy
Positive Regulation Of Mitochondrial Membrane Potential
Suppression By Virus Of Host Apoptotic Process
Cytokine-mediated Signaling Pathway
Cerebral Cortex Development
Positive Regulation Of Insulin Secretion
Response To Estradiol
Response To Progesterone
Positive Regulation Of Glucokinase Activity
Response To Testosterone
Response To Oleic Acid
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Drug
Response To Hydrogen Peroxide
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Type B Pancreatic Cell Proliferation
Response To Ethanol
Positive Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Proteolysis
ADP Metabolic Process
ATP Metabolic Process
Regulation Of Mitochondrial Membrane Permeability
Pore Complex Assembly
Positive Regulation Of Epithelial Cell Proliferation
Response To Glucocorticoid
Response To Calcium Ion
Positive Regulation Of Apoptotic Process By Virus
Cellular Response To Chromate
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Lipid
Cellular Response To Hypoxia
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Response To Benzene
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Granulosa Cell Apoptotic Process
Positive Regulation Of Type B Pancreatic Cell Development
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Transferrin endocytosis and recycling
Activation of BAD and translocation to mitochondria
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Navitoclax
Diseases
GWAS
Cocaine dependence (
23958962
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
Renal cell carcinoma x sex interaction (
31231134
)
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Platelet count (
22423221
)
Sarcoidosis (
22837380
)
Vitiligo (
27723757
)
Interacting Genes
6 interacting genes:
BAD
BNIP3L
MTDH
PKMYT1
SETD7
TPT1
45 interacting genes:
ACTN2
AKT1
ARAF
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BRAF
CDKN1A
CREB3L3
EWSR1
HRK
KEAP1
KRT31
MAP2K5
MAPK8
MCL1
PAK1
PAK5
PIM1
PIM2
PIM3
PPP1CA
PPP3CA
PRDX2
PRKACA
PRKCI
RAF1
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA5
S100A10
SFN
SNCA
STEAP3
SUMO2
WASF1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
55240
572
HPRD ID
10285
04409
Ensembl ID
ENSG00000115107
ENSG00000002330
Uniprot IDs
A1P3F0
B8ZZX6
Q658P3
A0A024R562
Q92934
PDB IDs
2VNS
2VQ3
1G5J
Enriched GO Terms of Interacting Partners
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