SETD7 and L3MBTL1

Data Source:
BioGRID (pull down)

		SETD7	L3MBTL1
Description		SET domain containing 7, histone lysine methyltransferase	L3MBTL histone methyl-lysine binding protein 1
Image
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Plasma Membrane
	Molecular Function	P53 Binding Chromatin Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Nucleosomal Histone Binding SAM Domain Binding Methylated Histone Binding Histone Binding Identical Protein Binding
	Biological Process	Chromatin Organization Cellular Response To DNA Damage Stimulus Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Response To Ethanol Positive Regulation Of Transcription, DNA-templated Regulation Of Histone H3-K9 Methylation Heterochromatin Organization	Chromatin Organization Regulation Of Mitotic Nuclear Division Hemopoiesis Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Regulation Of Signal Transduction By P53 Class Mediator
Pathways		PKMTs methylate histone lysines	Regulation of TP53 Activity through Methylation
Drugs		S-adenosyl-L-homocysteine	2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS		Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)	Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917)
Interacting Genes		29 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21	7 interacting genes: CBX3 ETV6 ETV7 H1-5 H4-16 RB1 SETD7
Entrez ID		80854	26013
HPRD ID		16226	16387
Ensembl ID		ENSG00000145391	ENSG00000185513
Uniprot IDs		B5MCZ8 D6RJA0 Q8WTS6	Q9Y468
PDB IDs		1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT	1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN 6BYB
Enriched GO Terms of Interacting Partners?
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