L3MBTL1 and CBX3

Data Source:
HPRD (in vivo, in vitro)

		L3MBTL1	CBX3
Description		L3MBTL histone methyl-lysine binding protein 1	chromobox 3
Image
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Plasma Membrane	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Nucleosomal Histone Binding SAM Domain Binding Methylated Histone Binding Histone Binding Identical Protein Binding	Protein Binding Transcription Factor Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Chromatin Organization Regulation Of Mitotic Nuclear Division Hemopoiesis Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Regulation Of Signal Transduction By P53 Class Mediator	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of G0 To G1 Transition Cellular Response To Dexamethasone Stimulus
Pathways		Regulation of TP53 Activity through Methylation	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs		2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS		Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917)	Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: CBX3 ETV6 ETV7 H1-5 H4-16 RB1 SETD7	46 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LRIF1 MGA MIS12 MKI67 MRPL12 NSD3 NSL1 PIM1 PRR14 RAD54L2 SP100 STK16 SUV39H1 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280C ZNF280D ZNF496
Entrez ID		26013	11335
HPRD ID		16387	05130
Ensembl ID		ENSG00000185513	ENSG00000122565
Uniprot IDs		Q9Y468	A4D177 Q13185
PDB IDs		1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN 6BYB	2L11 3DM1 3KUP 3TZD 5T1I 6HW2
Enriched GO Terms of Interacting Partners?
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