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REEP4 and HSD3B7
Data Source:
BioGRID
(two hybrid)
REEP4
HSD3B7
Description
receptor accessory protein 4
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytoplasmic Microtubule
Membrane
Integral Component Of Membrane
Endoplasmic Reticulum Tubular Network
Endoplasmic Reticulum Membrane
Lipid Droplet
Integral Component Of Membrane
Molecular Function
Protein Binding
Microtubule Binding
3-beta-hydroxy-delta5-steroid Dehydrogenase Activity
Protein Binding
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
Biological Process
Nuclear Envelope Organization
Mitotic Nuclear Envelope Reassembly
Cell Division
Endoplasmic Reticulum Tubular Network Organization
Bile Acid Biosynthetic Process
B Cell Chemotaxis
Pathways
Olfactory Signaling Pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs
Diseases
Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS
Hypertriglyceridemia (
23505323
)
Interacting Genes
97 interacting genes:
AGPAT4
BCL2L1
BET1
BIK
BMP10
C14orf180
C1S
C2CD2L
C4orf3
CCL4L2
CLDND2
CMTM3
COMT
CTSA
CYB5B
CYB5R3
CYP4F2
DCBLD2
DERL1
DGAT2L6
DNAJC30
ERG28
FAM241B
FBXO7
FMO1
FUNDC2
GIMAP1
GYPB
HSD3B7
HTATIP2
IFITM3
ITGAM
LEMD1
LEMD3
LEPROTL1
LNPEP
MAL2
MOSPD3
MS4A1
NCK2
ORMDL1
PEX16
PLP2
PMP22
PRAF2
RTP2
RTP4
SEC22B
SELENOK
SELENOM
SERF1A
SERF1B
SERP1
SFT2D1
SFT2D2
SFXN2
SFXN3
SLC25A46
SLC30A8
SLC7A8
SMAGP
SMIM1
SQLE
STATH
STX3
STX5
SYNJ2BP
TIMM22
TMEM120B
TMEM121
TMEM128
TMEM167B
TMEM18
TMEM19
TMEM199
TMEM208
TMEM229B
TMEM254
TMEM50A
TMEM51
TMEM60
TMEM65
TMEM86A
TMX2
TPRG1
TSNARE1
TSPAN2
TVP23B
UBE2J1
UBIAD1
UNC50
VAMP1
VAMP4
VAPB
VTI1B
YIF1A
YIPF4
58 interacting genes:
ADAMTSL4
AGR2
ANAPC11
APPBP2
ARID5A
ASB12
BTN2A2
C22orf39
COMT
CREB5
CYSRT1
DAPP1
EFEMP1
EFEMP2
EGFL7
ELOVL4
EMG1
FBLN2
GLRX3
HOXA1
HSD17B13
ICAM1
KPNA4
KPRP
KRT31
KRT40
KRT86
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP13-3
KRTAP19-2
KRTAP4-2
KRTAP5-9
LCE4A
LINGO1
MEI4
MEOX2
MGAT5B
NOTCH2NLA
NR4A3
OTX2
PYGL
RBP3
REEP4
RGS17
RUSF1
SPRY2
SSC4D
TMEM31
TMX2
TRIM42
YPEL3
ZBTB42
ZNF655
Entrez ID
80346
80270
HPRD ID
09864
09680
Ensembl ID
ENSG00000168476
ENSG00000099377
Uniprot IDs
E5RGS2
Q9H6H4
Q9H2F3
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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