HSD3B7 and KRTAP13-3

Data Source:
BioGRID (two hybrid)

		HSD3B7	KRTAP13-3
Description		hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	keratin associated protein 13-3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane	Cytosol Intermediate Filament
	Molecular Function	3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity	Protein Binding
	Biological Process	Bile Acid Biosynthetic Process B Cell Chemotaxis	Keratinization
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Keratinization
Drugs
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC) Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS
Interacting Genes		58 interacting genes: ADAMTSL4 AGR2 ANAPC11 APPBP2 ARID5A ASB12 BTN2A2 C22orf39 COMT CREB5 CYSRT1 DAPP1 EFEMP1 EFEMP2 EGFL7 ELOVL4 EMG1 FBLN2 GLRX3 HOXA1 HSD17B13 ICAM1 KPNA4 KPRP KRT31 KRT40 KRT86 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-2 KRTAP4-2 KRTAP5-9 LCE4A LINGO1 MEI4 MEOX2 MGAT5B NOTCH2NLA NR4A3 OTX2 PYGL RBP3 REEP4 RGS17 RUSF1 SPRY2 SSC4D TMEM31 TMX2 TRIM42 YPEL3 ZBTB42 ZNF655	68 interacting genes: ATG9A ATXN1 C14orf119 C1orf109 CCDC102B CCDC120 CCDC57 CLIC3 COL8A1 CRYBA1 CRYBA2 CYSRT1 DTX2 EFEMP2 FAH FOXH1 GATA2 GNE GPANK1 GPSM3 GUCD1 HEXIM2 HOXA1 HOXC8 HSD3B7 KCTD7 KCTD9 KPRP KRT83 KRTAP10-1 KRTAP10-11 KRTAP12-3 KRTAP3-1 KRTAP3-2 KRTAP5-11 KRTAP5-6 KRTAP9-2 KRTAP9-3 LNX1 LONRF1 MGAT5B MLX NBPF19 NEK6 NOTCH2NLA OTX1 PAX9 PCSK5 POU4F2 R3HDM2 RBPMS RUNX1T1 SLIT1 SMARCC1 SPAG8 TCP11 TEKT4 TLE5 TLX3 TOLLIP TRIM59 TRIM68 TSSK3 UBL5 VWC2 ZNF319 ZNF330 ZNF414
Entrez ID		80270	337960
HPRD ID		09680	11202
Ensembl ID		ENSG00000099377	ENSG00000240432
Uniprot IDs		Q9H2F3	Q3SY46
PDB IDs
Enriched GO Terms of Interacting Partners?
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