HSD3B7 and RBP3

Data Source:
BioGRID (two hybrid)

		HSD3B7	RBP3
Description		hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	retinol binding protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane	Extracellular Region Extracellular Space Cone Matrix Sheath Extracellular Vesicle
	Molecular Function	3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity	Retinoid Binding Protein Binding Serine-type Peptidase Activity Retinal Binding Retinol Binding
	Biological Process	Bile Acid Biosynthetic Process B Cell Chemotaxis	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Visual Perception
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol	The retinoid cycle in cones (daylight vision) The canonical retinoid cycle in rods (twilight vision)
Drugs			Lapachone
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC) Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS			Corneal curvature ( 24963161) Macular thickness ( 30535121)
Interacting Genes		58 interacting genes: ADAMTSL4 AGR2 ANAPC11 APPBP2 ARID5A ASB12 BTN2A2 C22orf39 COMT CREB5 CYSRT1 DAPP1 EFEMP1 EFEMP2 EGFL7 ELOVL4 EMG1 FBLN2 GLRX3 HOXA1 HSD17B13 ICAM1 KPNA4 KPRP KRT31 KRT40 KRT86 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-2 KRTAP4-2 KRTAP5-9 LCE4A LINGO1 MEI4 MEOX2 MGAT5B NOTCH2NLA NR4A3 OTX2 PYGL RBP3 REEP4 RGS17 RUSF1 SPRY2 SSC4D TMEM31 TMX2 TRIM42 YPEL3 ZBTB42 ZNF655	15 interacting genes: CDC23 CREB5 CYSRT1 EFEMP2 HOXA1 HR HSD3B7 KPRP KRTAP10-5 MGAT5B NID2 NOTCH1 PLSCR4 POU4F2 SPAG8
Entrez ID		80270	5949
HPRD ID		09680	01581
Ensembl ID		ENSG00000099377	ENSG00000265203
Uniprot IDs		Q9H2F3	P10745
PDB IDs
Enriched GO Terms of Interacting Partners?
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