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HSD3B7 and ARID5A
Data Source:
BioGRID
(two hybrid)
HSD3B7
ARID5A
Description
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
AT-rich interaction domain 5A
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Lipid Droplet
Integral Component Of Membrane
Nucleus
Nucleoplasm
Nucleolus
Molecular Function
3-beta-hydroxy-delta5-steroid Dehydrogenase Activity
Protein Binding
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Transcription Corepressor Activity
RNA Binding
Protein Binding
Transcription Factor Binding
Estrogen Receptor Binding
Identical Protein Binding
Sequence-specific DNA Binding
Retinoid X Receptor Binding
Thyroid Hormone Receptor Binding
Androgen Receptor Binding
Biological Process
Bile Acid Biosynthetic Process
B Cell Chemotaxis
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Cellular Response To Estrogen Stimulus
Pathways
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs
Diseases
Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Event-related brain oscillations (
21184583
)
Interacting Genes
58 interacting genes:
ADAMTSL4
AGR2
ANAPC11
APPBP2
ARID5A
ASB12
BTN2A2
C22orf39
COMT
CREB5
CYSRT1
DAPP1
EFEMP1
EFEMP2
EGFL7
ELOVL4
EMG1
FBLN2
GLRX3
HOXA1
HSD17B13
ICAM1
KPNA4
KPRP
KRT31
KRT40
KRT86
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP13-3
KRTAP19-2
KRTAP4-2
KRTAP5-9
LCE4A
LINGO1
MEI4
MEOX2
MGAT5B
NOTCH2NLA
NR4A3
OTX2
PYGL
RBP3
REEP4
RGS17
RUSF1
SPRY2
SSC4D
TMEM31
TMX2
TRIM42
YPEL3
ZBTB42
ZNF655
127 interacting genes:
ANKRD11
AR
ATP6V0D2
ATXN1
ATXN1L
BAG4
BAHD1
BANP
BOLL
C14orf119
C19orf54
CAMK2A
CATSPER1
CCDC120
CCDC57
CKS1B
COX5B
CRYBA1
CRYBA2
CYSRT1
DAB1
DAZAP2
DOK6
DTX2
ESR2
ESRP1
FAM168B
FHL3
FOXD2
FOXH1
GATA5
GLIS2
GOLGA2
GRB2
HDAC7
HOXA1
HSD3B7
INIP
IRX6
KAZN
KCTD9
KDF1
KRT40
KRTAP10-8
KRTAP12-2
KRTAP12-4
KRTAP15-1
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP22-1
KRTAP26-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
LASP1
LENG8
LIMS3
LIMS4
LITAF
LMO2
MAB21L2
MAGED1
MDFI
MIEN1
MKRN3
MORN3
MYLIP
NUDT22
ODAM
OLIG3
OTX1
PHF1
PIBF1
PIN1
PITX1
PLA2G10
PLAGL2
PLEKHN1
PNMA1
POU1F1
PRDM6
PRKAB2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QRICH1
RARA
RBFOX1
RBPMS
RBPMS2
RFC5
RHOXF2
RNF44
ROR2
RXRA
SEC24A
SH2D2A
SMYD1
SOHLH1
SOX5
TEKT3
TEKT4
TENT5A
TENT5D
TGM7
THRA
TNS2
TRAF1
TRIM27
TRIM73
TSC1
TSEN15
TSSK3
UBTD2
USP20
VAC14
VENTX
ZC3H10
ZIC1
ZNF503
ZNF765
Entrez ID
80270
10865
HPRD ID
09680
12481
Ensembl ID
ENSG00000099377
ENSG00000196843
Uniprot IDs
Q9H2F3
Q03989
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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