REEP4 and SQLE

Data Source:
BioGRID (two hybrid)

		REEP4	SQLE
Description		receptor accessory protein 4	squalene epoxidase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Integral Component Of Membrane Endoplasmic Reticulum Tubular Network	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Microtubule Binding	Squalene Monooxygenase Activity Protein Binding FAD Binding
	Biological Process	Nuclear Envelope Organization Mitotic Nuclear Envelope Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization	Cholesterol Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cholesterol Metabolic Process Response To Organic Substance Sterol Biosynthetic Process Regulation Of Cell Population Proliferation Regulation Of Cholesterol Biosynthetic Process Lipid Droplet Formation
Pathways		Olfactory Signaling Pathway	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			Naftifine Terbinafine Butenafine Ellagic acid
Diseases
GWAS		Hypertriglyceridemia ( 23505323)	Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Metabolite levels ( 23823483)
Interacting Genes		97 interacting genes: AGPAT4 BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L C4orf3 CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM167B TMEM18 TMEM19 TMEM199 TMEM208 TMEM229B TMEM254 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VTI1B YIF1A YIPF4	6 interacting genes: ALDOC CREB3 CREB3L1 REEP4 TMEM14B ZNF641
Entrez ID		80346	6713
HPRD ID		09864	11802
Ensembl ID		ENSG00000168476	ENSG00000104549
Uniprot IDs		E5RGS2 Q9H6H4	Q14534 Q5HYI4
PDB IDs			6C6N 6C6P 6C6R
Enriched GO Terms of Interacting Partners?
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