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HSD3B7 and ASB12
Data Source:
BioGRID
(two hybrid)
HSD3B7
ASB12
Description
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
ankyrin repeat and SOCS box containing 12
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Lipid Droplet
Integral Component Of Membrane
Ubiquitin Ligase Complex
Cytosol
Molecular Function
3-beta-hydroxy-delta5-steroid Dehydrogenase Activity
Protein Binding
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Bile Acid Biosynthetic Process
B Cell Chemotaxis
Protein Ubiquitination
Post-translational Protein Modification
Pathways
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS
Interacting Genes
58 interacting genes:
ADAMTSL4
AGR2
ANAPC11
APPBP2
ARID5A
ASB12
BTN2A2
C22orf39
COMT
CREB5
CYSRT1
DAPP1
EFEMP1
EFEMP2
EGFL7
ELOVL4
EMG1
FBLN2
GLRX3
HOXA1
HSD17B13
ICAM1
KPNA4
KPRP
KRT31
KRT40
KRT86
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP13-3
KRTAP19-2
KRTAP4-2
KRTAP5-9
LCE4A
LINGO1
MEI4
MEOX2
MGAT5B
NOTCH2NLA
NR4A3
OTX2
PYGL
RBP3
REEP4
RGS17
RUSF1
SPRY2
SSC4D
TMEM31
TMX2
TRIM42
YPEL3
ZBTB42
ZNF655
8 interacting genes:
EPHB6
HGS
HSD3B7
KLHL38
LENG1
LZTR1
TLX3
TSEN15
Entrez ID
80270
142689
HPRD ID
09680
06451
Ensembl ID
ENSG00000099377
ENSG00000198881
Uniprot IDs
Q9H2F3
Q8WXK4
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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