LHX3 and CCDC6

Data Source:
BioGRID (two hybrid)

		LHX3	CCDC6
Description		LIM homeobox 3	coiled-coil domain containing 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytosol Cytoskeleton
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Identical Protein Binding
	Biological Process	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development	Cytoskeleton Organization Biological_process
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Thyroid cancer
GWAS		Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 28552196 20189936) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)	Alopecia areata ( 25608926) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		78 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL C2CD6 CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GAS8 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LHX1 LMX1A MAPK9 NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TLE5 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 YY1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76	32 interacting genes: ATF2 ATF5 CCDC136 CCDC33 CENPQ CREB1 CSNK2A1 CYTH4 FBXW7 GAS8 LHX3 LRSAM1 LUZP4 MAPK3 MAPK7 MEOX2 MTUS2 PAX6 PIN1 PPP4C SH3RF1 SNAPC1 SORBS3 TFIP11 TRIM14 UBE2I WAC ZNF250 ZNF354C ZNF620 ZNF774 ZNF835
Entrez ID		8022	8030
HPRD ID		02783	09064
Ensembl ID		ENSG00000107187	ENSG00000108091
Uniprot IDs		F1T0D5 F1T0D9 Q9UBR4	Q05CP8 Q16204
PDB IDs
Enriched GO Terms of Interacting Partners?
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